Alex Frickenstein

Assistant Professor

Email: africk256@ou.edu
Phone: (405) 325-4427
Office: Gallogly Hall 420

Education

Ph.D., Biomedical Engineering
University of Oklahoma
B.S., Chemical and Biological Engineering
Colorado State University

RESEARCH FOCUS

Engineering education
Online teaching resources
Single particle analysis

PROFESSIONAL AND OUTREACH INTERESTS

During his doctoral training and research, Dr. Frickenstein focused on engineering and characterizing monodisperse gold nanoparticles for use in improving the quantification of nanoscale interactions between cells, proteins, and nanoparticles. Dr. Frickenstein specialized in quantification of inorganic nanoparticles through single particle inductively coupled mass spectrometry. Dr. Frickenstein’s current interests include:

Engineering Education: improving accessibility, comprehension, and applicability of biomedical engineering knowledge and skills through enhancing instruction
Virtual Learning Platforms: capitalizing on novel online opportunities for training biomedical engineers in higher education, professional, and industry pursuits

Dr. Frickenstein is not accepting Ph.D. students at this time.

Selected Publications

A complete list of Dr. Frickenstein’s publications can be found on Google Scholar.

Frickenstein A, Means A, He Y, Whitehead L, Harcourt T, Malik Z, Sheth V, Longacre L, Taffe H, Wang L, McSpadden I, Baroody C, Yan W, Zhao D, Wilhelm S, “The Predictive Synthesis of Monodisperse and Biocompatible Gold Nanoparticles,” ACS Appl. Nano Mater., 2024, 7 (19), 23250-23269, DOI: 10.1021/acsanm.4c04838
Scott R, Frickenstein A, Wilhelm S, “Longitudinal Analysis of Strategies for Improving Biomedical Engineering Student Knowledge of Career Paths and Desired Skillsets,” ASEE, 2024, 44315, Link: https://nemo.asee.org/public/conferences/344/papers/44315/view
Wang L, Sheth V, Liu K, Panja P, Frickenstein A, He Y, Yang W, Thomas A, Jamei M, Park J, Lyu S, Donahue N, Chen W, Bhattacharya R, Mukherjee P, Wilhelm S, “Primary Human Breast Cancer-Associated Endothelial Cells Favor Interactions with Nanomedicines,” Adv. Mater., 2024, 2403986, DOI: 10.1002/adma.202403986
Wang L, Quine S, Frickenstein A, Lee M, Yang W, Sheth V, Bourlon M, He Y, Lyu S, Garcia-Contreras L, Zhao Y, Wilhelm S, "Exploring and Analyzing the Systemic Delivery Barriers for Nanoparticles," Adv. Funct. Mater., 2023, 34, 2308446, DOI: 10.1002/adfm.202308446
Haddad M^, Frickenstein A^, Wilhelm S, “High-Throughput Single-Cell Analysis of Nanoparticle-Cell Interactions,” TrAC, 2023, 166, DOI: 10.1016/j.trac.2023.117172
Frickenstein A^, Mukherjee S^, Harcourt T, He Y, Sheth V, Wang L, Malik Z, Wilhelm S, “Quantification of Biocompatible Monodisperse Gold Nanoparticles by SP-ICP-MS,” Analytical and Bioanalytical Chemistry, 2023, https://doi.org/10.1007/s00216-023-04540-x
Yang W, Frickenstein A, Holden A, Sheth V, Mettenbrink E, Wang L, Woodward A, Joo B, Butterfield S, Donahue N, Green D, Thomas A, Harcourt T, Young H, Tang M, Malik Z, Harrison R, Mukherjee P, DeAngelis P, Wilhelm S, “Controlling nanoparticle uptake in innate immune cells with heparosan polysaccharides,” Nano Letters, 2022, 22 (17), 7119-7128, DOI: 10.1021/acs.nanolett.2c02226
Donahue N, Sheth V, Frickenstein A, Holden A, Kanapilly S, Chady S, Wilhelm S, “Absolute quantification of nanoparticle interactions with individual human B cells by single cell mass spectrometry,” Nano Letters, 2022, 22 (10), 4192-4199, 10.1021/acs.nanolett.2c01037
Frickenstein A, Hagood J, Britten C, Abbott B, McNally M, Vopat C, Patterson E, MacCuaig W, Jain A, Walter K, McNally L, “Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect,” Pharmaceutics, 2021, 13 (4), 570, DOI: 10.3390/pharmaceutics13040570