The Samuel Roberts Noble Microscopy Laboratory, the core microscopy facility of the University of Oklahoma-Norman, offers access to instrumentation, training, and service.
Our mission is to provide effective and efficient access to core imaging and analytical characterization technologies. We welcome all OU-Norman, OUHSC, and OMRF student, faculty, and staff researchers at our centralized location the OU-Norman main campus. Clients from other universities, foundations and industry are welcome to use this equipment as well, and such work may be done on an invoice or contract basis.
In addition to instrument access, SRNML personnel offer advice, hands-on training, education, and research collaboration. We have a range of sample preparation equipment available; our staff work with users and provide training. The SRNML aims to promote, enable, and encourage cutting-edge education and research using the core’s instrumentation. Please see our Using SRNML page to get started, and don’t hesitate to contact us.
Become a User, Take a Course, Schedule a Visit or Consultation, and Participate in events
In addition to acknowledgement or co-authorship resulting from technical support and collaboration with SRNML personnel, published data resulting from facility use should include an acknowledgement such as, "Microscopy data collection was performed at the Samuel Roberts Noble Microscopy Laboratory, an OU core facility supported by the Vice President for Research and Partnerships".
Submit your published manuscripts with SRNML acknowledgement or co-authorship to srnml@ou.edu to receive $100 credit towards future facility use.
We send email updates regarding events, instrument and lab resources, opportunities, etc. from time to time. If you would like to be included in our mailing list, please submit your email address below.
You are invited to attend the research presentations for the Graduate Certificate in Microscopic Imaging & Technology program Thursday Dec. 12th at 10 am - 12 pm at SRNML conference room. This is an opportunity for our students in the certificate program to present their research work related to microscopes or microscopic applications. Your presence will be a great support to our students and our graduate certificate program.
The fall semester is coming to an end, and at SRNML is means that students taking the TEM lab course will be giving their final presentations. The students have been working hard all semester to get TEM data for their research projects after learning how to use our high resolution 2010F microscope. Please join us in the SRNML conference room at 9am on Dec 10th to see all the great work they have been doing!
Prof. Tony Wilson, University of Oxford (Emeritus), Past President of the Royal Microscopy Society and past Editor of the Journal of Microscopy, will be presenting the lecture "Confocal Microscopy Today". All are welcome Monday, December 9th at 1 pm in the SRNML conference room. Prof. Wilson was a key developer of the laser confocal scanning microscope and structured illumination microscopy. We hope to see you there to welcome one of the great pioneers of confocal microscopy!
I am pleased to announce that the ThermoFisher Tundra cryo-TEM, a first in the State of Oklahoma, has been installed, inspected, tested, and is now available for trained users. In celebration of this joint venture and incredible endeavor, we would like to invite you to attend our Grand Opening Event at the Stephenson Life Sciences Research Center on Thursday, December 5, 2024, at 4 pm. The celebration will take place on the 1st Floor North Lounge. We will celebrate with some refreshments, a formal ribbon cutting, a few words to commemorate this event, and small group tours of the facility.
Our workhorse JEOL 2010F with an ultimate resolution of 1Å was recently upgraded with a Nanosprint 12 scientific CMOS camera. This lens-based system allows for high doses and exceptional sensitivity on a wide range of samples. Coupled with the microscope’s STEM and EDS capabilities, new technique development opportunities abound to extend the lifespan of our existing toolset. Reach out to Julian and try it out! Image and corresponding diffraction pattern of gold nanoparticles taken by Julian using the new AMT camera.
This easy-to-use reflected light materials microscope / metallograph is now available for use at no charge to users. Microscope capabilities include: fully motorized xyz stage, 1229 x 968 resolution camera, large area montaging and automated image stitching., brightfield and darkfield imaging needed for grain size analysis and surface quality measurements respectively , up to approximately 3000x fully optical magnification, and Axiovision Pro software for acquisition and analysis.
The ThermoFisher Tundra cryo-TEM is currently undergoing installation in SLSRC 1655. We will definitely send an update when the system is fully operational and ready for users. Shown here is the first-of-its kind sample loading station, allowing samples already frozen in vitreous ice to be loaded into the microscope at liquid nitrogen temperatures. The primary microscope function is to assist in the process of solving protein/macromolecular structures via single particle analysis. Researchers from the OU COBRE in Structural Biology team have experience collecting and analyzing SPA data for cryo-TEM projects at national cryo-EM research facilities. The Tundra will dramatically improve the ability of Oklahoma researchers to screen grids and decrease the time from identification of a system/ molecule of interest to obtaining a structure.
In addition to the reflected light polarizer, our Keyence digital microscope now has a fully rotatable polarizer/ analyzer setup for transmitted light microscopy. Thanks to several OU faculty, the OU Center for Quantum Research and Technology, OptoKhemia Analytical, and particularly the Furis research group for making this possible.
With the award of an NSF MRI and support from the OVPRP, OU has purchased a JEOL NeoARM 200kV aberration corrected STEM materials specific microscope. This state-of-the-art instrument will allow researchers to probe the structures of materials down to an ultimate resolution of 70 pm. With a DECTRIS Ela hybrid-pixel direct electron camera coupled to a CEOS energy filter / EELS, electronic structures of thin films, energy and battery materials, and other semiconductor devices will be able to be investigated on the atomic level. Additionally a high throughput EDS detector allows for quick chemical mapping of all samples imaged on the microscope, leading the way for researchers to quickly investigate all aspects of their materials down to the atomic level. Room B21 Lin Hall is currently undergoing renovations to prepare for the microscope, which we hope will be installed by early 2025.
