Macromolecular Crystallography Laboratory

The Biomolecular Structure Core - Norman facility is also known as the Macromolecular Crystallography Laboratory. The facility is part of the NIH sponsored Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) and is located in the Stephenson Life Sciences Center at the University of Oklahoma - Norman Research Campus. The laboratory provides intellectual and instrument resources for structure determination of macromolecules. Services range from conducting initial crystallization trials to single crystal X-ray diffraction and structure determination of biomacromolecules molecules (proteins and nucleic acids). We provide assistance and guidance from initial crystallization trials to a completed structure for internal and external research groups. The BSC is also equipped with instrumentation for cryoEM sample preparation.

Complementary services are provided by the BSC-OKC facility at the OU Health Sciences Center.

The facility is supported by a combination of funds from the University of Oklahoma Department of Chemistry and Biochemistry, NIH, NSF and user fees.

Funded in part by Institutional Development Awards (IDeA) from the National Institutes of General Medical Sciences of the National Institutes of Health (Awards P20GM103640 and P30GM145423) and by the National Science Foundation (Award 0922269).