Macromolecular Crystallography Laboratory (MCL)

The MCL provides all necessary resources for structure determination of macromolecules. Services range from conduction initial crystallization trials to single crystal x-ray diffraction and structure determination of macromolecular molecules (proteins and nucleic acids). We provide help and guidance from initial crystallization trials to a completed structure for internal and external research groups.

Services (fee based)

• Crystallization of macromolecules
• Production of optimization crystallization screens and trials
• Single crystal X-ray diffraction data collection and processing for macromolecules 
• Structure determination of macromolecules
• Deposition of structural data
• Training in all aspects of crystal growth, X-ray data collection, structure solution and refinement 

Instruments (fee based)

• Rigaku MicroMax 007HF microfocus X-ray generator. 
• Dectris Pilatus 200K silicon pixel detector mounted on a AFC11  4-axis  goniometer
• Oxford Cryosystems Cryostream 700 Series is utilized for low temperature data collection 
• Rigaku RAXIS IV++ image plate detector
• Linux workstations using with current crystallographic software for data processing and structure determination.
• LN2 dewars are available for long-term crystal storage
• TTP Labtech Mosquito nanoliter liquid handler
• Art Robbins Instruments Scorpion liquid handler
• Formulatrix Rock Imager 1000 with UV and Multi Fluorescence Imaging capabilities 
  
• Rigaku DT Minstrel Imager and plate hotel
• Leica M205 with MC170HD digital camera
• Various microscopes and tools for sample handling