My long-term research goal is to understand the fundamental physical interactions in RNA in order to predict RNA structures, functions, small molecule interactions, and drug targets from sequence. My lab probes structure-function relations in viral RNA and virus-host interactions using nanopore and Illumina sequencing, chemical probing, nuclear magnetic resonance, crystallography, and UV optical melting, as well as a diverse array of biophysical, molecular biology, sequencing, and computational techniques. My lab aims to discover the role of RNA and RNA modifications in the symbiotic relationships when RNA viruses help plants survive drought. My lab studies diverse RNA, including Satellite Tobacco Mosaic Virus RNA, Human Endogenous Retroviral RNA, influenza, plant noncoding RNA, and novel RNA yet to be discovered.
Plant Single-Cell/Nucleus RNA-seq Workflow. Thibivilliers S, Farmer A, Schroeder S, Libault M. Methods Mol Biol. 2023;2584:165-181. doi: 10.1007/978-1-0716-2756-3_6. PMID: 36495448
Nearest neighbor rules for RNA helix folding thermodynamics: improved end effects. Zuber J, Schroeder SJ, Sun H, Turner DH, Mathews DH. Nucleic Acids Res. 2022 May 20;50(9):5251-5262. doi: 10.1093/nar/gkac261.PMID: 35524574
"Novel pRNA three-way junctions,” Alyssa C. Hill, Susan J. Schroeder, University of Oklahoma, US Patent Office approval date January 26, 2021 patent # 10900035. international application number PCT/US2017/019556.
Advancing viral RNA structure prediction: measuring the thermodynamics of pyrimidine-rich internal loops. Phan A, Mailey K, Saeki J, Gu X, Schroeder SJ.RNA. 2017 May;23(5):770-781. doi: 10.1261/rna.059865.116. Epub 2017 Feb 17. PMID: 28213527
Challenges and approaches to predicting RNA with multiple functional structures. Schroeder SJ.RNA. 2018 Dec;24(12):1615-1624. doi: 10.1261/rna.067827.118. Epub 2018 Aug 24. PMID: 30143552
