Yang

EDUCATION

Ph.D. Telecom ParisTech, France

RESEARCH INTERESTS

• Assess the connectivity between neuronal populations
• Understand how brain adapts and reorganizes after an injury and during the recovery
• Develop engineering-based targeted intervention for brain injuries

GRANTS & AWARDS

• NIH NICHD R01 HD109157, Title: Shift from unilateral to bilateral sensory-motor connectivity in chronic hemiparetic stroke, 09/18/2022 - 08/31/2027, $ 1,636,183

• American Heart Association Career Development Award (#932980), Title: Determine the effect of targeted high-definition tDCS on reducing post-stroke upper limb motor impairments, 07/01/2022 – 06/30/2025, $ 231,000

• NIH NICHD R21 HD099710, Title: Determination of the recruitment of indirect motor pathways in chronic hemiparetic stroke, 07/01/2019- 06/30/2023, $ 416,079

• OCAST HR21-164, Title: Multimodal integration of concurrent high-density EEG-fMRI with diffusion and anatomical MRI to determine dynamic information flow in brain circuits – an application to hemiparetic stroke, 11/01/2021-10/31/2024, $ 135,000 

• OSCTR Pilot, Title: Targeted HD-tDCS for reducing post-stroke movement impairments, 01/01/22-06/30/23, $ 72,500

• CoBRE Pilot, Title: Probing sex difference in brain networks and the relation with the MAD psychopathology, 01/01/2021-12/31/2021, $ 77,500

SELECTED PUBLICATIONS

1. Williamson J. N, Sikora W. A, James S. A, Parmar N. J, Lepak L.V, Cheema C.F., Refai H.H, Wu D. H, Sidorov E.V, Dewald J. P. A, Yang Y (2022), Cortical Reorganization of Early Somatosensory Processing in Hemiparetic Stroke, Journal of Clinical Medicine, 11(21):6449.

2. Williamson J. N, Yabluchanskiy A, Mukli P, Wu DH, Sonntag W, Ciro C, Yang Y (2022), Sex Differences in Brain Functional Connectivity of Hippocampus in Mild Cognitive Impairment. Frontiers in Aging Neuroscience. 14:959394. PMID: 36034134, PMCID: PMC9399646. 

3. Vasudeva B, Tian R, Wu D.H., James S.A., Refai, H.H., Ding L, Yang Y (2022), Multi-Phase Locking Value: A Generalized Method for Determining Instantaneous Multi-Frequency Phase Coupling, Biomedical Signal Processing and Control, 74 (2022): 103492, PMID: 35111233 PMCID: PMC8803274.

4. Tian R, Dewald J.P.A. Yang Y (2021), Assessing the Usage of Indirect Motor Pathways following a Hemiparetic Stroke, IEEE Trans Neural Syst Rehabilitation Eng; 29:1568-72, PMID: 34343095 PMCID: PMC8372540.

5. He, F., Yang, Y. (2021). Nonlinear System Identification of Neural Systems from Neurophysiological Signals. Neuroscience. 458: 213-228, PMID: 33309967, PMCID: PMC7925423.

6. Tian R, Dewald J.P.A, Sinha N, Yang Y (2021), Assessing Neural Connectivity and Associated Time Delays of Muscle Responses to Continuous Position Perturbations, Annals of Biomedical Engineering, 49(1):432-440. PMID: 32705425, PMCID: PMC7775285.

7. Gu Y, Yang Y, Dewald J.P.A, van der Helm F.C.T., Schouten A.C., and Wei H-L (2020), Nonlinear Modeling of Cortical Responses to Mechanical Wrist Perturbations using the NARMAX Method, IEEE Transactions on Biomedical Engineering, Accepted. DOI: 10.1109/TBME.2020.3013545.

8. Tian R, Dewald J.P.A, Sinha N, Yang Y (2020), Assessing neural connectivity and associated time delays of muscle responses to continuous position perturbations, Annals of Biomedical Engineering, in press, DOI: 10.1007/s10439-020-02573-2.

9.  Sinha N, Heckman C.J, Dewald J.P.A, Yang Y (2020), Cross-frequency coupling in descending motor pathways: theory and simulation, Frontiers in System Neuroscience, 13:86, PMID: 31992973, PMCID: PMC6971171.

10.  Yang Y, Sinha N, Tian R, Gurari N, Drogos JM, Dewald J.P.A. (2020), Quantifying altered neural connectivity of the stretch reflex in chronic hemiparetic stroke. IEEE Transactions on Neural System and Rehabilitation Engineering, 28(6): 1436-1441, PMID: 32275603.

11. Yang Y, Yao J, Dewald J.P.A, van der Helm F.C.T, Schouten A.C (2020), Quantifying the Nonlinear Interaction in the Nervous System based on Phase-locked Amplitude Relationship, IEEE Transactions on Biomedical Engineering, doi: 10.1109/TBME.2020.2967079, [Epub ahead of print], PMID: 31976876.

12. Yang Y, Dewald, J. P. A., van der Helm, F. C. T and Schouten, A. C (2018), Unveiling neural coupling within the sensorimotor system: directionality and nonlinearity. European Journal of Neuroscience, 48(7): 2407-2415. PMID: 28887885 PMCID: 28887885.

13. Hu X, Zhao T, Yao J, Kuang Y, Yang Y (2018), Advances in Neural Engineering for Rehabilitation, Behavioural Neurology, 2018: 9240921 PMID: 29422721 PMCID: 29422721.

14. Filatova OG*, Yang Y*, Dewald JPA, Tian R, Maceira-Elvira P, Takeda Y, Kwakkel G, Yamashita O, and van der Helm FCT (2018), Dynamic information flow based on EEG and diffusion MRI in stroke: a proof-of-principle study, Frontiers in Neural Circuits, 2018; 12: 79. PMCID: PMC6174251, PMID: 30327592 (*co-first authorship).

15. Tang Y, Liu B, Yang Y, Wang C, Li M, Tang B, Guo J (2018). Identifying mild-moderate Parkinson's disease using whole-brain functional connectivity, Clinical Neurophysiology, 129(12):2507-2516, PMID: 30347309.

16. Tian, R*, Yang, Y*, van der Helm, F.C. and Dewald, JPA (2018). A novel approach for modeling neural responses to joint perturbations using the NARMAX method and a hierarchical neural network. Frontiers in Computational Neuroscience, 12: 96. PMCID: PMC6291451 (*co-first authorship).

17. Gursel Ozmen N., Gumusel L. and Yang Y (2018). A Biologically Inspired Approach to Frequency Domain Feature Extraction for EEG Classification. Computational and Mathematical Methods in Medicine, 2018: 9890132. PMCID: PMC5896285, PMID: 29796060.

18.  Yang Y, Guliyev B and Schouten AC (2017) Dynamic Causal Modeling of the Cortical Responses to Wrist Perturbations. Frontiers in Neuroscience, 11:518. PMID: 28955197 PMCID: PMC5601387.

19. Yang Y, Solis-Escalante T, Yao J, Daffertshofer A, Schouten A.C., and van der Helm F.C.T. (2016), A general approach for quantifying nonlinear connectivity in the nervous system based on phase coupling, International Journal of Neural Systems, 26 (1): 1550031. PMID: 26404514 (annual best paper award).

20. Yang Y, Solis-Escalante T, Yao J, van der Helm F.C.T, Dewald J.P.A and Schouten A.C (2016), Nonlinear Connectivity in the Human Stretch Reflex Assessed by Cross-frequency Phase Coupling, International Journal of Neural Systems, 26(8): 1650043, PMID: 27440467.

21. Yang Y, Solis-Escalante T, van der Helm F.C.T, Schouten A.C (2016), A generalized coherence framework for detecting and characterizing nonlinear interactions in the nervous system, IEEE Transactions on Biomedical Engineering, 63(12): 2629-2637, PMID: 27362753.

22. Yang Y, Solis-Escalante T, van de Ruit M, van der Helm F.C.T and Schouten A.C (2016), Nonlinear coupling between cortical oscillations and muscle activity during isotonic wrist flexion, Frontiers in Computational Neuroscience, 10:126. PMID: 27999537 PMCID: 27999537.

GRANTS & AWARDS

• NIH NICHD R01 HD109157, Title: Shift from unilateral to bilateral sensory-motor connectivity in chronic hemiparetic stroke, 09/18/2022 - 08/31/2027, $ 1,636,183

• American Heart Association Career Development Award (#932980), Title: Determine the effect of targeted high-definition tDCS on reducing post-stroke upper limb motor impairments, 07/01/2022 – 06/30/2025, $ 231,000

• NIH NICHD R21 HD099710, Title: Determination of the recruitment of indirect motor pathways in chronic hemiparetic stroke, 07/01/2019- 06/30/2023, $ 416,079

• OCAST HR21-164, Title: Multimodal integration of concurrent high-density EEG-fMRI with diffusion and anatomical MRI to determine dynamic information flow in brain circuits – an application to hemiparetic stroke, 11/01/2021-10/31/2024, $ 135,000 

• OSCTR Pilot, Title: Targeted HD-tDCS for reducing post-stroke movement impairments, 01/01/22-06/30/23, $ 72,500

• CoBRE Pilot, Title: Probing sex difference in brain networks and the relation with the MAD psychopathology, 01/01/2021-12/31/2021, $ 77,500