NEWS
OKLAHOMA CITY – In 2010, University of Oklahoma researcher David Fields, Ph.D., was pouring over research data when he discovered something he thought was odd: His data showed that at 6 months of age, formula-fed babies born of mothers who were categorized as medically obese weighed about 5% units less fat than breastfed babies in the same dataset. That discovery struck him as unusual and led him on a research journey to better understand breast milk. Now, he’s studying the connections between maternal gestational diabetes, breastfeeding and infant health.
Fields is part of the research team behind a recent study in The Journal of the American Medical Association that examines the effects of breast milk on the children of mothers with gestational diabetes.
“Gestational diabetes is a big deal,” said Fields, an associate professor of pediatrics in the OU College of Medicine. “It’s bad for the mother because, while it goes away after giving birth, it usually portends that later in life, the mother will get diabetes.”
Fields and his colleagues began studying mother-infant pairs with gestational diabetes in 2019, when the National Institutes for Health renewed funding for his 2015 project with University of Minnesota researcher Ellen Demerath, Ph.D., called the Mothers and Infants LinKed for Health Growth (MILK) study, one of the largest and longest-running studies on breastfeeding in the country.
At that time, Fields suspected the breast milk composition of mothers with gestational diabetes would be different from mothers without the disease. When they began digging into the compositional differences between breast milk for mothers with and without gestational diabetes, the results told an unexpected story. While nine differences existed between the breast milk of mothers with gestational diabetes and those without, three were significantly associated with growth and body composition. Those differences benefitted the children of mothers with gestational diabetes.
Babies of mothers with gestational diabetes had faster linear growth: They were longer and growing faster. They also had a lower fat percentage in one month to three months.
“They weren’t putting on fat as much, which is totally opposite of what we would think. We thought that these babies would be gaining more fat, but they’re not,” Fields said.
When the MILK study began, very little was known about the composition of breast milk. “We didn’t know much beyond macronutrients, simply how much fat and how much protein is in the milk,” he said.
And while there is still more to learn about the differences between formula and breast milk, and their effects on children, Fields and his team are at the forefront of making those discoveries.
“Our ultimate take-home message is milk is medicine. Milk is the interface between the baby and the mother. What a mother eats and how they live, either good or bad, is being signaled and transferred to the infant,” Fields said.
About the research
“Gestational Diabetes, the Human Milk Metabolome, and Infant Growth and Adiposity” is published in The Journal of the American Medical Association at https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827802. Field’s current study, “Maternal Obesity, Breast Milk Composition, and Infant Growth,” in collaboration with Ellen Demerath, Ph.D., at the University of Minnesota, is funded by the National Institutes of Health.
About the University of Oklahoma
Founded in 1890, the University of Oklahoma is a public research university with campuses in Norman, Oklahoma City and Tulsa. As the state’s flagship university, OU serves the educational, cultural, economic and health care needs of the state, region and nation. In Oklahoma City, OU Health Sciences is one of the nation’s few academic health centers with seven health profession colleges located on the same campus. OU Health Sciences serves approximately 4,000 students in more than 70 undergraduate and graduate degree programs spanning Oklahoma City and Tulsa and is the leading research institution in Oklahoma. For more information about OU Health Sciences, visit www.ouhsc.edu.
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