Amal Eltobshi

Major Professor: Fornelli
Email: amal.m.eltobshi-1@ou.edu

Hometown:
Egypt

Secondary School:
El-Orman Secondary School

Education:
Bachelor, Pharmaceutical Sciences, Faculty of Pharmacy - Cairo University
Master's, Biochemistry, Faculty of Pharmacy - Cairo University

Understanding the human body and what are the factors that contribute to the development of disease are the major driving force that made me interested in studying biochemistry. After bachelor degree, I started my master degree and studied the association of single nucleotide polymorphism (SNP) and long non-coding RNA (lncRNA) with colorectal and breast cancer.

Currently I am working in Fornelli Lab on Top-down proteomic to characterize high molecular wight proteins, apolipoprotein. This would enable identifying the various proteoforms of the protein. Proteoforms are different forms of the protein that arises from genetic variation, alternative splicing of mRNA and post-translational modifications of the protein. Understanding the proteoform difference between individual can provide additional information for understanding disease phenotype.

My goal after getting PhD. degree is to continue studying how the combined genetic, epigenetic, and proteomic variations alter the normal function contributing to development and severity of diseases such as cancer. I am also interested in understanding how these variations contribute to different response of individuals to treatments.

Publications, Presentations & Awards

Publications

Abd El-Fattah AA, Sadik NA, Shaker OG, Kamal AM, Shahin NN. Serum Long Non-Coding RNAs PVT1, HOTAIR, and NEAT1 as Potential Biomarkers in Egyptian Women with Breast Cancer. Biomolecules. 2021 Feb (18), 11(2):301. Doi: 10.3390/biom11020301.
Abd El-Fattah AA, Sadik NA, Shaker OG, Kamal AM. Single nucleotide polymorphism in SMAD7 and CHI3L1 and colorectal cancer risk. Mediators of inflammation. 2018 Oct (23), 9853192. Doi: 10.1155/2018/9853192.
Abd El-Fattah AA, Sadik NA, Shaker OG, Kamal AM. Are SMAD7 rs4939827 and CHI3L1 rs4950928 polymorphisms associated with colorectal cancer in Egyptian patients? Tumour Biol. 2016 Jul;37(7):9387-97. Doi: 10.1007/s13277-016-4813-8.

Presentations

Amal M. Kamal, Jake T. Kline, Kenneth R. Durbin, Ryan N. Oates, and Luca Fornelli. Top-down mass spectrometry analysis of apolipoprotein A4 (apoA-IV) from pooled serum samples utilizing proton transfer charge reduction (PTCR). 70Th ASMS conference, Minneapolis, MN, June 6-9, 2022 [poster presenter]
Amal M. Kamal, Jake T. Kline, Kenneth R. Durbin, Ryan N. Oates, and Luca Fornelli. Proton transfer charge reduction (PTCR) improves the gas-phase sequencing of intact proteins >30 kDa. 69Th ASMS conference, Philadelphia, PA, October 31 - November 4, 2021 [poster presenter]

Awards

Dodge Family Research Fellowship, 2023
Cairo University Publication Award, 2018