Integrative Immunology Center

Dr. Teague holds the George Kaiser Family Foundation Chair in Community Medicine Research.  His research focuses on psychoneuroimmunology (PNI). He is the Integrative Immunology Center Director and the Associate Dean for Research at the University of Oklahoma School of Community Medicine.  Dr. Teague is a professor in the Department of Surgery and an adjunct professor in the Department of Psychiatry at the School of Community Medicine.  He is also an adjunct associate professor at the Oklahoma State University Center for Health Sciences and an adjunct professor at the University of Oklahoma College of Pharmacy.  He completed his Ph.D. in Biological Sciences at the University of Texas M.D. Anderson Cancer Center in Houston.  He completed a postdoctoral fellowship in Immunology at the Howard Hughes Medical Institute at the National Jewish Research Center in Denver.  

Kent-teague@ouhsc.edu  

ORCID iD: 0000-0002-4680-5440

 

Ashlee Rempel serves as the Integrative Immunology Center Laboratory Manager and Business Manager.  Ashlee has been employed at the University of Oklahoma since 2002, beginning as a Research Assistant II in the Department of Pediatrics at the OUHSC in Oklahoma City.  She joined OU - Tulsa as a Research Assistant II in 2005.  She assumed the role of Research Associate and Laboratory Manager in 2009.  She has a Bachelor of Science in Microbiology and a Master's in Business Administration from Oklahoma State University.  She is a certified flow cytometrist and an expert in flow-based cytokine bead arrays, ELISA, MSD arrays, Illumina Nextgen sequencing, and other biomarker technologies.

Ashlee-rempel@ouhsc.edu

 

Dr. Tan directs the Flow Cytometry Laboratory at the Integrative Immunology Center.  He is an expert in multiparametric flow cytometry.  He is a certified operator of the MoFlo™ XDP high-speed cell sorter.  He earned his PhD in Polymer Chemistry and Physics at the Chinese Academy of Sciences, Beijing, China.  He completed a postdoctoral fellowship in Biochemistry and Biophysics at the OUHSC in Oklahoma City and a second postdoctoral fellowship in Immunology at the University of Oklahoma School of Community Medicine in Tulsa.

Chibing-tan@ouhsc.edu

 

Brenda Davis is a senior research technician with extensive experience in human tissue/blood processing, blood and saliva biomarker analyses,  molecular biology and recombinant DNA technology.  She serves as the Integrative Immunology Center’s clinical studies coordinator and oversees human tissue processing and cryogenic storage. She earned a Bachelor of Science in Biochemistry from The Oklahoma State University.  

Brenda-davis@ouhsc.edu   

Dr. Marino is a volunteer faculty member in the Department of Surgery at the University of Oklahoma, School of Community Medicine, Tulsa.  She received her Bachelor of Arts in Biology from Covenant College before completing her PhD in Immunology at the University of Tulsa. She completed post-doctoral training in the Department of Surgery at the University of Oklahoma College of Medicine in Tulsa.  Her efforts at the Integrative Immunology Center focus on delivery of immunology curriculum to learners at all levels.

Julie-marino@ouhsc.edu  

 

Dr Richards is an obesity medicine physician in the Department of Internal Medicine.  He is passionate about understanding the neuroendocrine drivers of obesity and studying the mechanisms underlying genetic, syndromic, and hypothalamic obesity.  He also works on novel treatments for substance use disorders in collaboration with the Oklahoma State University Center for Health Sciences.  Dr Richards works clinically as the Director of Obesity Medicine and is Associate Program Director for the Internal Medicine residency program. He is involved in clinical trial design of both obesity and psychiatric disorder treatment in collaboration with the OU Health Stephenson Cancer center.

Jesse-R-Richards@ouhsc.edu

Dr. Ford is an Assistant Professor at the Oklahoma State University Center for Health Sciences in the Department of Pharmacology and Physiology.  He  earned a PhD from the University of Tulsa in Behavioral Immunology.  His laboratory (BILT)  focuses on biobehavioral determinants of immune function.  He is currently a Research Project Leader for the NIGMS P20 CoBRE project the Center for Integrative Research on Childhood Adversity (CIRCA) for which the Integrative Immunology Center serves as part of the Biological Systems Core.

Bart.ford@okstate.edu

 

Jonathan Savitz, Ph.D. Principal Investigator, Laureate Institute for Brain Research and Associate Professor, University of Tulsa

Projects:

NIMH R01MH123652: Neural response to inflammatory challenge in major depressive disorder. The main goals of this project are aimed at 1) elucidating the neural circuitry underlying a maladaptive homeostatic response to inflammation in MDD by using a placebo-controlled transient inflammatory response and 2) identifying brain targets relevant to inflammation-induced depression.

 

NINDS - R01NS135776: The role of cytomegalovirus in the physiological and clinical effects of concussion

 

NIGMS P20GM131212: The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP): Research Core. The goal of the NeuroMAP is to establish  a  program  to  train  junior  researchers  with  a  pragmatic  focus  to  use  neuroscience  to  improve  mental  health. The components of the Research Core are organized to examine specific units of analyses and create an integrated infrastructure: (A) Symptoms & Behavior, (B) Circuits & Physiology, (C) Cells & Molecules, (D) Intervention, (E) Biostatistics, and (F) IT & Database.

 

Timothy Meier, Ph.D Associate Professor of Neurosurgery, Department of Neurosurgery

Project:

NINDS - R01NS135776: The role of cytomegalovirus in the physiological and clinical effects of concussion

 

Jennifer Hays-Grudo, Ph.D. Professor, Department of Psychiatry and Behavioral Sciences. Center for Integrative Research on Childhood Adversity, National Center for Wellness and Recovery

Projects:

NIMH U01DA055349: 10/24 Healthy Brain and Child Development National Consortium. The main goals of this project are to prospectively examine human brain, cognitive, behavioral, social and emotional development of children and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children.

NIGMS P20GM109097: Center for Integrative Research on Childhood Adversity - Biological Systems Core. The major goals of this project are to build Oklahoma State University-Tulsa’s (OSU-Tulsa) and OU-Tulsa's research environment focused on discovering the sources of health inequities among children and to translate scientific results into solutions that eliminate children’s health inequities. The Biological Systems Core is aimed at providing support for biomarker analyses for the center investigators.

 

Amanda Sheffield Morris, Ph.D. Regents' Professor and George Kaiser Family Foundation Endowed Chair in Child Development, Department of Psychiatry and Behavioral Sciences, Center for Integrative Research on Childhood Adversity

Projects:

NIMH U01DA055349: 10/24 Healthy Brain and Child Development National Consortium. The main goals of this project are to prospectively examine human brain, cognitive, behavioral, social and emotional development of children and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of childre

NIGMS P20GM1090907: Center for Integrated Research on Childhood Adversity

 

Julie Croff, PhD, Professor, Executive Director - Population and Clinical Research, National Center for Wellness and Recovery

Projects:

NIH - P20GM109097: Biological Systems Core co-Director - Center for Integrated Research on Childhood Adversity

NIMH U01DA055349: 10/24 Healthy Brain and Child Development National Consortium. The main goals of this project are to prospectively examine human brain, cognitive, behavioral, social and emotional development of children and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children.

Bart Ford, PhD. Assistant Professor, Department of  Pharmacology and Physiology

Project: 

Brain & Behavior Research Foundation: Immune Predictors of SARS-CoV-2 Vaccine Response in Major Depressive Disorder. The main goal of this project is to examine the immune predictors of the adaptive immune response to SARS-CoV-2 vaccination in a sample of individuals with mood and anxiety disorders.

NIH - P20GM109097: Research Project Leader - Center for Integrated Research on Childhood Adversity - Immune Genomics and COVID-19 Response in Adults with Adverse Childhood Experiences.  This project examines how adverse childhood experiences may alter gene expression in two important classes of immune cells (monocytes and dendritic cells) in ways that affect COVID-19 vaccine efficacy.

 

David Bard, Ph.D. Director, Biomedical and Behavioral Methodology Core (BBMC) , Associate Professor, Department of Pediatrics, OU College of College of Medicine

Project: 

HRSA/OSDH UH4MC307450100: Maternal, Infant, and Early Childhood Home Visiting Program: A Collaborative Learning Innovation for Addressing Engagement/ Retention of Home Visiting

 

Karina Shreffler, Ph.D. Professor, College of Nursing, University of Oklahoma Health Science Center

Project: 

U54 HD113173 - Center for Indigenous Resilience, Culture, and Maternal Health Equity

 

 

Marianna Wetherill, Ph.D., M.P.H., RDN/LD, Associate Professor, Department of Health Promotions Sciences, Hudson College of Public Health and Department of Family and Community Medicine, School of Community Medicine

Project: 

NIDDK R01DK127464: Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma. The major goals of this project are to identify how food insecurity contributes to insulin resistance in HIV and to evaluate a “food as medicine” intervention designed to lower insulin resistance for people living with HIV.

 

 

Brett McKinney, Ph.D Professor of Computer Science, William K. Warren, Jr. Endowed Chair in Bioinformatics, College of Engineering and Natural Sciences

Project:

NIGMS P20GM131212: Neuroscience-Based Mental Health Assessment and Prediction (NeuroMAP)- Center of Biomedical Research Excellence - Research Core. The goal of the NeuroMAP is to establish  a  program  to  train  junior  researchers  with  a  pragmatic  focus  to  use  neuroscience  to  improve  mental  health. The components of the Research Core are organized to examine specific units of analyses and create an integrated infrastructure: (A) Symptoms & Behavior, (B) Circuits & Physiology, (C) Cells & Molecules, (D) Intervention, (E) Biostatistics, and (F) IT & Database.

 

1.     Figueroa-Hall, L. K., Burrows, K., Alarbi, A. M., Hannafon, B. N., Hladik, C., Tan, C., Ramesh, R., Stewart, J. L., Risbrough, V. B., Paulus, M. P., Teague, T. K.  (2025). Comparison of methods for isolation and characterization of total and astrocyte-enriched extracellular vesicles from human serum and plasma. Journal of Extracellular Biology. PMID: 39958973.

2.     Savitz, J., McKinney, B. A., Meier, T. B., Zheng, H., Ford, B. N., Yolken, R. H., Teague, T. K., Cole, S. W. (2025). Nuclear factor kappa-B cell (NF-κB), interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection. Brain, Behavior, and Immunity, 123, 1052-1060. PMID: 39532200.

3.     Meier, T. B., Savitz, J., Espana, L. Y., Goeckner, B. D., Teague, T. K., van der Horn, H. J., Muftuler, L. T., Mayer, A. R., Brett, B. L. (2025). Association of concussion history with psychiatric symptoms, limbic system structure, and kynurenine pathway metabolites in healthy, collegiate-aged athletes. Brain, Behavior, and Immunity, 123, 619-630. PMID: 39414174.

4.     Munshi, S., Alarbi, A., Zheng, H., Kuplicki, R., Burrows, K., Figueroa-Hall, L., Victor, T., Aupperle, R., Khalsa, S., Paulus, M. P., Teague, T. K., Savitz, J.  (2024). Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder. Molecular Psychiatry. PMID: 38260352.

5.     Zhang, Y., Munshi, S., Burrows, K., Kuplicki, R., Figueroa-Hall, L. K., Aupperle, R., Khalsa, S. S., Teague, T. K., Taki, Y., Paulus, M. P., Savitz, J., Zheng, H. (2024). Leptin’s Inverse Association with Brain Morphology and Depressive Symptoms – A Discovery and Confirmatory Study Across Two Independent Samples. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(7), 714-725. PMID: 38631553.

6.     Burrows, K., Figueroa-Hall, L., Stewart, J., Alarbi, A., Kuplicki, R., Hannafon, B., Tan, C., Risbrough, V., McKinney, B., Ramesh, R., Victor, T., Aupperle, R., Savitz, J., Teague, T. K., Khalsa, S., Paulus, M. P. (2024). Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder. Translational Psychiatry, 14, 199. PMID: 38678012.

7.     Keirns, B. H., Keirns, N. G., Tsotsoros, C. E., Layman, H. M., Stout, M. E., Medlin, A. R., Sciarrillo, C. M., Teague, T. K., Emerson, S. R., Hawkins, M. A. (2023). Adverse childhood experiences and obesity linked to indicators of gut permeability and inflammation in adult women. Physiology & Behavior, 271, 114319. PMID: 37562704.

8.     Burrows, K., McNaughton, B., Figueroa-Hall, L., Spechler, P., Kuplicki, R., Victor, T., Aupperle, R., Khalsa, S., Savitz, J., Teague, T. K., Paulus, M., Stewart, J. (2023). Elevated serum leptin is associated with attenuated reward anticipation in major depressive disorder independent of peripheral C-reactive protein levels. Scientific Reports, 13(1), 11313. PMID: 37443383.

9.     Savitz, J., Goeckner, B. D., Ford, B. N., Teague, T. K., Zheng, H., Harezlak, J., Mannix, R., Muftuler, L. T., Brett, B. L., McCrea, M. A., Meier, T. B.  (2023). The effects of cytomegalovirus on brain structure following sport-related concussion. Brain. PMID: 37070698.

10.  Rogers, E. M., Banks, N. F., Tomco, P. M., Sciarrillo, C. M., Emerson, S. R., Thomas, E. B., Taylor, A., Teague, T. K., Jenkins, N. D.  (2023). Progressive exercise training improves cardiovascular psychophysiological outcomes in young adult women with a history of adverse childhood experiences. Journal of Applied Physiology, 134(3), 742-752. PMID: 36727632.

11.  Burrows, K., Figueroa-Hall, L. K., Alarbi, A. M., Stewart, J. L., Kuplicki, R., Tan, C., Hannafon, B. N., Ramesh, R., Savitz, J., Khalsa, S., Teague, T. K., Risbrough, V. B., Paulus, M. P.  (2023). Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals. Brain, Behavior, & Immunity - Health, 27, 100582. PMID: 36605933.

12.  Savitz, J. , Ford, B. N., Kuplicki, R., Khalsa, S., Teague, T. K., Paulus, M. P. (2022). Acute Administration of Ibuprofen Increases Serum Concentration of the Neuroprotective Kynurenine Pathway Metabolite, Kynurenic Acid: a pilot randomized, placebo-controlled, cross-over study. Psychopharmacology, 239(12), 3919-3927. PMID: 36271950.

13.  Zheng, H., Teague, T. K., Yeh, F.-C., Burrows, K., Figueroa-Hall, L. K., Aupperle, R. L., Khalsa, S. S., Paulus, M. P., Savitz, J.  (2022). C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder. Brain, Behavior, and Immunity, 105, 180-189. PMID: 35853557.

14.  Tsotsoros, C. E., Stout, M. E., Medlin, A. R., Wideman, L., Vazquez Sanroman, D., Tan, C., Teague, T. K., Hawkins, M. A.W.  (2022). Pilot Associations between Adverse Childhood Experiences, Executive Function, and Brain-Derived Neurotrophic Factor (BDNF) among Adults with Excess Adiposity. Obesities, 2, 276-284.

15.  Wetherill, M. S. , Bakhsh, C., Caywood, L., Williams, M. B., Hartwell, M. L., Wheeler, D. L., Hubach, R. D., Teague, T. K., Köhler, G., Hebert, J. R., Weiser, S. D. (2022). Unpacking determinants and consequences of food insecurity for insulin resistance among people living with HIV: Conceptual framework and protocol for the NOURISH-OK study. Frontiers in Clinical Diabetes and Healthcare, 3, 947552. PMID: 36225538.

16.  Figureroa-Hall, L., Xu, B., Kuplicki, Ford, B., Burrows, K., Teague, T. K., Sen, S., Yeh, H.-W., Irwin, M., Savitz, J., Paulus, M.  (2022). Psychiatric symptoms are not associated with circulating CRP concentrations after controlling for medical, social, and demographic factors. Translational Psychiatry, 12(1), 279. PMID: 35821205.

17.  Burrows, K., Figueroa-Hall, L. K., Kuplicki, R., Stewart, J. L., Alarbi, A. M. , Ramesh, R., Savitz, J. B., Teague, T. K., Risbrough, V. B., Paulus, M. P.  (2022). Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial. Scientific Reports, 12(1), 861. PMID: 35039595.

18.  MacGregor, T., Savitz, J., Zhang, Y., Burrows, K., Smith, R., Figueroa-Hall, L., Kuplicki, R., Khalsa, S. S., Taki, Y., Teague, T. K., Irwin, M. R., Yeh, F.-C., Paulus, M. P., Zheng, H.  (2021). Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression. Life, 12(1), 43. PMID: 35054436.

19.  Meier, T. , Guedes, V. , Smith, E., Sass, D., Mithani, S., Vorn, R., Savitz, J., Teague, T. K., McCrea, M., Gill, J. (2021). Extracellular vesicle-associated cytokines in sport-related concussion. Brain, Behavior, and Immunity, 100, 83-87. PMID: 34848337.

20.  Zheng, H. , Ford, B. N., Kuplicki, R., Burrows, K., Hunt, P. W., Bodurka, J., Teague, T. K., Irwin, M. R., Yolken, R. H., Paulus, M. P., Savitz (2021). Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension. Translational Psychiatry, 11(1), 464. PMID: 34493708.

21.  Jenkins, N. D. , Rogers, E. M., Banks, N. F., Tomco, P. M., Sciarrillo, C. M., Emerson, S. R., Taylor, A., Teague, T. K. (2021). Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood. Am J Physiol Heart Circ Physiol, 321(3), 532-541. PMID: 34328346

22.  Kuplicki, R. , Touthang, J., Al Zoubi, O., Mayeli, A., Misaki, M., Investigators, N., Aupperle, R. L., Teague, T. K., McKinney, B. A., Paulus, M. P., Bodurka, J.  (2021). Common Data Elements, Scalable Data Management Infrastructure and Analytics Workflows for Large-scale Neuroimaging Studies. Frontiers in Psychiatry. PMID: 34220587.

23.  Cosgrove, K. T., Kuplicki, R., Savitz, J., Simmons, K., Khalsa, S. S., Aupperle, R. L., Teague, T. K., Paulus, M. P. (2021). Impact of ibuprofen and peroxisome proliferator-activated receptor gamma on emotion-related neural activation: A randomized, placebo-controlled trial. Brain, Behavior, and Immunity. PMID: 34052365.

24.  Cohen, Z. P., Cosgrove, K. T., Akeman, E., Coffey, S., Teague, K., Hays-Grudo, J., Paulus, M. P., Aupperle, R. L., Kirlic, N.  (2021). The effect of a mindfulness-based stress intervention on neurobiological and symptom measures in adolescents with early life stress: a randomized feasibility study. BMC Complementary Medicine and Therapies, 21, 123. PMID: 33858395.

25.  Burrows, K. , Ste, J. L., Kuplicki, R., Figueroa-Hall, L., Spechler, P. A., Zheng, H., Guinjoan, S. M., Tulsa 1000 Investigators, Savitz, J. B., Teague, T. K., Paulus, M. P. (2021). Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder. Brain, Behavior, and Immunity, 93, 214-225. PMID: 33508469.

26.  Blair, A., Chiaf, A. L., Crockett, E. K., Teague, T. K., Croff, J. M.  (2021). Validation of Hair Ethyl Glucuronide Using Transdermal Monitoring and Self-Reported Alcohol Use in Women of Childbearing Potential. Neuropsychopharmacology Reports. PMID: 33650766.

27.  Meier, T. B. , España, L. E., Nitta, M. E., Teague, T. K., Brett, B. L., Nelson, L. D., McCrea, M. A., Savitz, J. (2021). Positive association between serum quinolinic acid and functional connectivity following concussion. Brain, Behavior, and Immunity, 91, 531-540. PMID: 33176183.

28.  Shreffler, K. M. , Joachims, C. N., Tiemeyer, S., Simmons, W. K., Teague, T. K., Hays-Grudo, J. (2021). Childhood Adversity and Perceived Distress from the COVID-19 Pandemic. Adversity and Resilience Science. PMID: 33527096.

29.  Zheng, H. , Bergamino, M., Ford, B. N., Kuplicki, R., Yeh, F.-C., Bodurka, J., Burrows, K., Tulsa 1000 Investigators, Hunt, P. W., Teague, T. K., Irwin, M. R., Yolken, R. H., Paulus, M. P., Savitz, J. (2021). Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder. Neuropsychopharmacology. PMID: 33500556.

30.  Tsuchiyagaito, A., Smith, J. L., El-Sabbagh, N., Zotev, V., Misaki, M., Al Zoubi, O., Teague, T. K., Paulus, M., Savitz, J., Bodurka, J.  (2021). Real-time fMRI Neurofeedback Amygdala Training May Influence Kynurenine Pathway Metabolism in Major Depressive Disorder. Neuroimage: Clinical, 29. PMID: 33516062.

31.  Savitz, J. , Ford, B. N., Yeh, H.-W., Akeman, E., Cosgrove, K., Clausen, A., Martell, C., Kirlic, N., Santiago, J., Teague, T. K., Irwin, M. R., Paulua, M. P., Aupperle, R. L.  (2020). Behavioral Activation Therapy for Depression Reduces the Concentration of Circulating Quinolinic Acid. Psychological Medicine. PMID: 33234171.

32.  Zheng, H., Ford, B., Bergamino, M., Kuplicki, R., Aupperle, R., Cha, Y.-H., Feinstein, J., Khalsa, S., Victor, T., Hunt, P., Bodurka, J., Teague, K., Irwin, M., Yolken, R., Paulus, M., Savitz, J.  (2020). A Hidden Menace? Cytomegalovirus Infection is Associated with Reduced Cortical Gray Matter Volume in Major Depressive Disorder. Molecular Psychiatry. PMID: 33223520.

33.  Brett, B., Savitz, J., Nitta, M., España, L., Teague, T. K., Nelson, L., McCrea, M., Meier, T. B.  (2020). Systemic inflammation moderates the association of prior concussion with hippocampal volume and episodic memory in high school and collegiate athletes. Brain, Behavior, and Immunity, 89, 380-388. PMID: 32717401.

34.  Meier, T. B. , Nitta, M. E., Teague, T. K., Nelson, L. D., McCrea, M. C., Savitz, J. (2020). Prospective study of the effects of sport-related concussion on serum kynurenine pathway metabolites. Brain, Behavior, and Immunity, 87, 715-724. PMID: 32147388.

35.  Ford, B. N. , Teague, T. K., Bayouth, M. , Yolken, R. H., Bodurka, J., Paulus, M. P., Irwin, M. R., Savitz, J. (2020). Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. Brain, Behavior, and Immunity, 87, 795-803. PMID: 32209361.

36.  Meier, T. B. , Huber, D. L., Bohorquez-Montoya, L., Morgan, N. E., Savitz, J., Teague, T. K., Bazarian, J. J., Hayes, R. L., Nelson, L. D., McCrea, M. A. (2020). A prospective study of acute blood-based biomarkers for sport-related concussion. Annals of Neurology, 87(6), 907-920. PMID: 32215965.

37.  Burrows, K., Stewart, J. L., Antonacci, C., Kuplicki, R., Thompson, K., Taylor, A., Teague, T. K., Paulus, M. P.  (2020). Association of poorer dietary quality and higher dietary inflammation with greater symptom severity in depressed individuals with appetite loss. Journal of Affective Disorders, 263, 99-106. PMID: 31818803.

38.  Croff, J. , Chibing, T., Chiaf, A. L., Hartwell, M. L., Crockett, E. K., Teague, T. K. (2020). Erythrocyte and Serum Folate Collection Techniques: A Multi-Method Study of Folate Status. Vitamins & Minerals, 9, 188.

39.  Cosgrove, K. T., Burrows, K., Avery, J. A., Kerr, K. L., DeVille, D. C., Aupperle, R. L., Teague, T. K., Drevets, W. C., Simmons, W. K. (2020). Appetite change profiles in depression exhibit differential relationships between systemic inflammation and activity in reward and interoceptive neurocircuitry. Brain, Behavior, and Immunity, 83, 163-171. PMID: 31604141.

40.  Croff, J. M., Chiaf, A. L., Hartwell, M. L., Crockett, E. K., Tan, C., Teague, T. K. (2019). Electronic Nicotine Delivery Systems and Serum Folate: A Case Study. Tobacco Use Insights, 12, 1-4. PMID: 31798305.

41.  Nitta, M., Savitz, J., Nelson, L., Teague, T. K., Hoelzle, J., McCrea, M., Meier, T. (2019). Acute elevation of serum inflammatory markers predicts symptom recovery after concussion. Neurology. PMID: 31270219.

42.  Ford, B. N., Yolken, R. H., Aupperle, R. L., Teague, T. K., Irwin, M. R., Paulus, M. P., Savitz, J. (2019). Association of Early-Life Stress With Cytomegalovirus Infection in Adults With Major Depressive Disorder. JAMA Psychiatry. PMID: 30840037.

43.  Ford, B. N., Yolken, R. H., Dickerson, F. B., Teague, T. K., Irwin, M. R., Paulus, M. P., Savitz, J. (2019). Reduced Immunity to Measles in Adults with Major Depressive Disorder. Psychological Medicine. PMID: 29552990.

44.  Le, T. T., Savitz, J., Suzuki, H., Misaki, M., Teague, T. K., White, B., Marino, J. H., Wiley, G., Gaffney, P., Drevets, W., McKinney, B., Bodurka, J. (2018). Identification and replication of RNA-Seq gene network modules associated with depression severity. Translational Psychiatry, 8(1), 180. PMID: 30185774.

45.  Simmons, K., Burrows, K., Avery, J., Kerr, K., Taylor, A., Bodurka, J., Potter, W., Teague, T. K., Drevets, W. (2018). Appetite Changes Reveal Depression Subgroups with Distinct Endocrine, Metabolic, and Immune States. Molecular Psychiatry. PMID: 29899546.

46.  Meier, T. B., Drevets, W. C., Teague, T. K., Wurfel, B. E., Mueller, S. C., Bodurka, J., Savitz, J. (2018). Kynurenic acid is reduced in females and oral contraceptive users: Implications for depression. Brain Behavior and Immunity, 67, 59-64. PMID: 28867283.

47.  Savitz, J., Teague, T. K., Misaki, M., Macaluso, M., Wurfel, B., Meyer, M., Drevets, D., Yates, W., Gleason, O. C., Drevets, W., Preskorn, S. (2018). Treatment of Bipolar Depression with Minocycline and/or Aspirin: An adaptive, 2 X 2 double-blind, randomized, placebo-controlled, phase IIA clinical trial. Translational Psychiatry, 8(27). PMID: 29362444.

48.  Suzuki, H., Savitz, J., Teague, T. K., Gandhapudi, S. K. , Tan, C., Misaki, M., McKinney, B. A., Irwin, M. R., Drevets, W. C., Bodurka, J. (2017). Altered Populations of Natural Killer Cells, Cytotoxic T Lymphocytes, and Regulatory T Cells in Major Depressive Disorder: Association with Sleep Disturbance. Brain, Behavior, and Immunity, 66, 193-200. PMID: 28645775.

49.  Cho, H. J., Savitz, J., Dantzer, R., Teague, T. K., Drevets, W. C., Irwin, M. R. (2017). Sleep disturbance and kynurenine metabolism in depression. Journal of Psychosomatic Research, 99, 1-7. PMID: 28712413.

50.  Wurfel, B. E., Drevets, W. C., Bliss, S. A., McMillin, J., Suzuki, H., Ford, B. N., Morris, H., Teague, T. K., Dantzer, R., Savitz, J. (2017). Serum Kynurenic Acid is Reduced in Affective Psychosis. Translational Psychiatry, 7(5), e1115. PMID: 28463241.

51.  Meier, T. B., Lancaster, M. A., Mayer, A. R., Teague, T. K., Savitz, J. (2017). Abnormalities in Functional Connectivity in Collegiate Football Athletes with and without a Concussion History: Implications and Role of Neuroactive Kynurenine Pathway Metabolites. Journal of neurotrauma, 34(4), 824-837. PMID: 27618518.

52.  Young, K. D., Drevets, W. C., Dantzer, R., Teague, T. K., Bodurka, J., Savitz, J. (2016). Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain, behavior, and immunity, 56, 335-42. PMID: 27091600.

53.  Meier, T. B., Savitz, J., Singh, R., Teague, T. K., Bellgowan, P. S. (2016). Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes. Journal of neurotrauma, 33(14), 1349-57. PMID: 26493952.

54.  Singh, R., Savitz, J., Teague, T. K., Polanski, D. W., Mayer, A. R., Bellgowan, P. S., Meier, T. B. (2016). Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion. Journal of neurology, neurosurgery, and psychiatry, 87(6), 670-5. PMID: 26269650.

55.  Meier, T. B., Drevets, W. C., Wurfel, B. E., Ford, B. N., Morris, H. M., Victor, T. A., Bodurka, J., Teague, T. K., Dantzer, R., Savitz, J. (2016). Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain, behavior, and immunity, 53, 39-48. PMID: 26546831.

56.  Meier, T. B., Bergamino, M., Bellgowan, P. S., Teague, T. K., Ling, J. M., Jeromin, A., Mayer, A. R. (2016). Longitudinal assessment of white matter abnormalities following sports-related concussion. Human brain mapping, 37(2), 833-45. PMID: 26663463.

57.  Savitz, J., Dantzer, R., Meier, T. B., Wurfel, B. E., Victor, T. A., McIntosh, S. A., Ford, B. N., Morris, H. M., Bodurka, J., Teague, T. K., Drevets, W. C. (2015). Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder. Psychoneuroendocrinology, 62, 54-8. PMID: 26232650.

58.  Savitz, J., Drevets, W. C., Wurfel, B. E., Ford, B. N., Bellgowan, P. S., Victor, T. A., Bodurka, J., Teague, T. K., Dantzer, R. (2015). Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain, behavior, and immunity, 46, 55-9. PMID: 25686798.

59.  Gandhapudi, S. K. , Tan, C., Marino, J. H., Taylor, A. A., Pack, C. C. , Gaikwad, J., Van De Wiele, C. J., Wren, J. D., Teague, T. K.  (2015). IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. Journal of immunology (Baltimore, Md. : 1950), 194(8), 3820-8. PMID: 25780034.

60.  Savitz, J., Dantzer, R., Wurfel, B. E., Victor, T. A., Ford, B. N., Bodurka, J., Bellgowan, P. S., Teague, T. K., Drevets, W. C. (2015). Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology, 52, 200-11. PMID: 25486577.

61.  Savitz, J., Drevets, W. C., Smith, C. M., Victor, T. A., Wurfel, B. E., Bellgowan, P. S., Bodurka, J., Teague, T. K., Dantzer, R. (2015). Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(2), 463-71. PMID: 25074636.

62.  Duffy, F. D., Miller-Cribbs, J. E., Clancy, G., Van De Wiele, C. J., Teague, T. K., Crow, S., Kollaja, E. A., Fox, M. D. (2014). Changing the culture of a medical school by orienting students and faculty toward community medicine. Academic medicine : journal of the Association of American Medical Colleges, 89(12), 1630-5. PMID: 25162616.

63.  Singh, R., Meier, T. B., Kuplicki, R., Savitz, J., Mukai, I., Cavanagh, L. E., Allen, T. W., Teague, T. K., Nerio, C., Polanski, D., Bellgowan, P. S. (2014). Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. JAMA, 311(18), 1883-8. PMID: 24825643.

64.  Savitz, J., Frank, M. B., Victor, T., Bebak, M., Marino, J. H., Bellgowan, P. S., McKinney, B. A., Bodurka, J., Teague, T. K., Drevets, W. C. (2013). Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain, Behavior, and Immunity, 31, 161-171. PMID: 23064081.

65.  Savitz, J., Preskorn, S., Teague, T. K., Drevets, D., Yates, W., Drevets, W. (2012). Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2x2 clinical trial. BMJ open, 2(1), e000643. PMID: 22357572.

66.  Tan, C. , Taylor, A. A., Coburn, M. Z. , Marino, J. H., Van De Wiele, C. J., Teague, T. K.  (2011). Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes. BMC immunology, 12, 36. PMID: 21689450.

67.  Li, X., Naylor, M. F., Le, H., Nordquist, R. E., Teague, T. K., Howard, C. Anthony, Murray, C., Chen, W. R. (2010). Clinical effects of in situ photoimmunotherapy on late-stage melanoma patients: a preliminary study. Cancer biology & therapy, 10(11), 1081-7. PMID: 20890121.

68.  Teague, T. K., Tan, C. , Marino, J. H., Davis, B. K., Taylor, A. A., Huey, R. W. , Van De Wiele, C. J. (2010). CD28 expression redefines thymocyte development during the pre-T to DP transition. International immunology, 22(5), 387-97. PMID: 20203098.

69.  Marino, J. H., Tan, C., Taylor, A. A., Bentley, C. , Van De Wiele, C. J., Ranne, R., Paliotta, M., Broughan, T. A., Teague, T. K.  (2010). Differential IL-7 responses in developing human thymocytes. Human immunology, 71(4), 329-33. PMID: 20074604.

70.  Marino, J. H. , Tan, C. , Davis, B., Han, E. S., Hickey, M., Naukam, R., Taylor, A., Miller, K. S., Van De Wiele, C. J., Teague, T. K.  (2008). Disruption of thymopoiesis in ST6Gal I-deficient mice. Glycobiology, 18(9), 719-26. PMID: 18535087.

71.  Broughan, T. A., Naukam, R., Tan, C. , Van De Wiele, C. J., Refai, H., Teague, T. K.  (2008). Effects of hepatic zonal oxygen levels on hepatocyte stress responses. The Journal of surgical research, 145(1), 150-60. PMID: 18164035.

72.  Van de Wiele, C. J., Marino, J. H. , Tan, C. , Kneale, H. A. , Weber, J. , Morelli, J. N. , Davis, B. K., Taylor, A. A., Teague, T. K.  (2007). Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cellular immunology, 250(1-2), 31-9. PMID: 18321477.

73.  Naylor, M. F., Chen, W. R., Teague, T. K., Perry, L. A., Nordquist, R. E. (2006). In situ photoimmunotherapy: a tumour-directed treatment for melanoma. The British journal of dermatology, 155(6), 1287-92. PMID: 17107404.

74.  Marino, J. H. , Van De Wiele, C. J. , Everhart, J. M. , Masengale, R., Naukam, R. J., Schniederjan, M. J. , Vo, S., Teague, T. K.  (2006). Attenuation of cytokine responsiveness during T cell development and differentiation. Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research, 26(10), 748-59. PMID: 17032169.

75.  Rao, R. S. , Howard, C. Anthony, Teague, T. K.  (2006). Pulmonary endothelial permeability is increased by fluid from packed red blood cell units but not by fluid from clinically-available washed units. The Journal of trauma, 60(4), 851-8. PMID: 16612308.

76.  Van De Wiele, C. J. , Marino, J. H. , Murray, B. W. , Vo, S. S., Whetsell, M. E., Teague, T. K.  (2004). Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. Journal of immunology (Baltimore, Md.: 1950), 172(7), 4235-44. PMID: 15034036.

77.  Van De Wiele, C. J., Marino, J. H., Whetsell, M. E., Vo, S. S., Masengale, R. M., Teague, T. K.  (2004). Loss of interferon-induced Stat1 phosphorylation in activated T cells. Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research, 24(3), 169-78. PMID: 15035850.

78.  Naylor, M. F., Crowson, N., Kuwahara, R., Teague, T. K., Garcia, C., Mackinnis, C., Haque, R., Odom, C., Jankey, C., Cornelison, R. L. (2003). Treatment of lentigo maligna with topical imiquimod. The British journal of dermatology, 149 Suppl 66, 66-70. PMID: 14616356.

79.  Mitchell, T. C., Teague, T. K., Hildeman, D. A., Bender, J., Rees, W. A., Kedl, R. M., Swanson, B., Kappler, J. W., Marrack, P. (2002). Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival. Annals of the New York Academy of Sciences, 975, 114-31. PMID: 12538159. 

Certified flow cytometrists: Ashlee Rempel, B.S., M.B.A. and Chibing Tan, Ph.D.

For instrument availability or laboratory protocol information contact:
Ashlee Rempel, B.S., M.B.A.
Phone: 918-660-3924
Fax: 918-660-3928
Email: ashlee-rempel@ouhsc.edu

 

AutoMACS cell sorter (Miltenyi Biotec) This instrument is used for magnetic bead cell enrichment and is used to quickly enrich cells from very large starting populations.

For laboratory protocol information contact:
Ashlee Rempel, BS, MBA
Phone: 918-660-3924
Fax: 918-660-3928
Email: ashlee-rempel@ouhsc.edu

MESO QUICKPLEX SQ 120 (Meso Scale Discovery) is an instrument designed for high-sensitivity multiplexed assays.  This instrument allows for highly sensitive analysis of cytokines and other biomarkers using small sample sizes and low inter-assay variability.

ImageQuant LAS4000 (GE) This hardware/software package allows for image capture and analysis of Western blots, DNA and PCR gels, culture dishes and microscope fields.

NextSeq 1000 (Illumina) is a benchtop next generation sequencing (NGS) system that uses XLEAP-SBS chemistry.

For laboratory protocol information contact:
Brenda Davis, BS
Phone: 918-660-3910
Fax: 918-660-3928
Email: brenda-davis@ouhsc.edu

 

P20GM109097 (Hays-Grudo) 09/06/2022– 06/30/2027

NIH/NIGMS

Center for Integrative Research on Childhood Adversity – The IIC serves as the biomarker core laboratories for the research projects and interventions for this multicenter project. The major goals of the project are to build a Tulsa research environment focused on discovering the sources of health inequities among children and to translate scientific results into solutions that eliminate children’s health inequities. 

P20GM131212 (Paulus) 09/15/2017 – 06/30/2028

NIH/NIGMS

The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP). The major goal of this project is to is to establish  a  program  to  train  junior  researchers  with  a  pragmatic  focus  to  use  neuroscience  to  improve  mental  health. – The IIC serves as a core biomarker laboratory for the research projects and interventions for this multicenter project.

U54 HD113173 (Friedman, Shreffler, Spicer, Van Wagoner) 07/01/2023 - 06/30/2030

NIH/NICHD

Center for Indigenous Resilience, Culture, and Maternal Health Equity (CIRCLE). The primary objective of this project is to establish a successful and self-sustaining center to understand and intervene to improve Indigenous maternal health. The IIC serves as a core biomarker laboratory for the subproject FLOURISH.

R01MH123652 (Meier, Savitz)  01/17/2024 - 06/30/2028

NIH/NIMH

The role of cytomegalovirus in the physiological and clinical effects of concussion. Through baseline and follow-up assessments of brain structure and function, blood-based biomarkers, and clinical phenotypes this study aims to test the hypothesis that CMV serostatus moderates SRC outcomes. The IIC is providing immunology expertise and laboratory support to the project.

R01MH123652 (Savitz)  04/01/2021 - 03/31/2026

NIH/NIMH

Neural response to inflammatory challenge in major depressive disorder: The aim of this research is to test how depressed and healthy individuals differ in their neural, immunological, and behavioral responses to an acute inflammatory challenge.  The IIC is providing immunology expertise and laboratory support to the project.

R01DK127464 (Wetherill)  09/17/2020 – 08/31/2025

NIH/NIDDK

Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma (NOURISH-OK): The goal of this project is to determine how food insecurity and chronic inflammation relate to insulin resistance via diet, other health behaviors, and the microbiome. The IIC laboratories are providing biomarker assessments for this study. 

 

BBRF Foundation Grant (Ford) 01/01/2022 - 12-31-2024

Immune Predictors of SARS-CoV-2 Vaccine Response in Major Depressive Disorder: The main goals of this project are to prospectively examine human brain, cognitive, behavioral, social and emotional development of children and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children.  The IIC is providing immunology expertise and laboratory support to the project.

 

HR21-021 (Criss) 12/01/2021 - 11/30/2024

OCAST

Link Between Chronic Adversity and Emerging Adult Mental and Physical Health: An Examination of Underlying Bio-Social Mechanisms and Protective Factors. The main goals of this project are to identify potential pathways linking social and environmental adversity, biological processes, and mental and physical health and to elucidate potential relationship processes that serve as protective factors.  The IIC is providing laboratory support to the project.