OTHER (ALSO GOOD) PROJECTS
(No particular Order)
EVALUATION OF SQUALESTATIN 1 AS AN ENZYME INHIBITOR FOR LOWERING CHOLESTEROL: In this presentation we analyze the feasibility of manufacturing and commercialization of a novel enzyme inhibitor (Squalestatin 1) of cholesterol synthesis. The goal is to propose a drug capable of lowering at least 50% of the total cholesterol level in patients dealing with high serum levels with the highest efficacy. This was done by analyzing the FDA and manufacturing processes, equipment pricing, manufacturing prices and determining highest demand for the drug, therefore, determining the best price for the drug. The success of this enterprise will mainly repose on the likelihood of its approval by the FDA and its marketing strategy. To establish this, the FDA process was subdivided with a specific goal at each step. Research has shown that Squalestatin 1 lowers serum cholesterol levels by 50% using a 10-20 mg/day dosage. The best price for this drug and the specified market was determined to be $1.33 per unit. The duration of the project is approximately 20 years including the FDA approval process. The total capital investment for this production is $68 million dollars with a manufacturing cost of $271 million/year. Based on the observed trends in NPV, ROI, and cash flow in addition to the benefits this drug would bring to a patient, it can be anticipated that the project will be successful.
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MICROCAPSULE-BASED DRUG DELIVERY: Significant advances in drug delivery technology have been made over the past two decades. One of the most important of these advances is the development of long acting drug injections. These long acting drug injections allow for a drug to be continually released for time periods exceeding one month. This biotechnology has obvious implications, such as higher patient compliance and the convenience of one dose opposed to multiple doses. Many drugs such as Haloperidol (a psychosomatic drug) and Naltrexone (an opioid antagonist drug) have recently been made available as long acting injections in the form of microspheres. Prescribing these long acting medications is no easy task. Doctors will need tools and methods to aid them in achieving optimal blood plasma drug concentrations (BPDC) in their patients. This presentation will overview one methodology that will allow doctors to prescribe the right amount and diamter distribution to be injected. An economic analysis is also included to assess the profitability of producing microsphere injections, specifically for alcoholism, in the pharmaceutical market.
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ANTICAVITY TOOTHPASTE DESIGN: Dental caries present a unique health problem and are considered a widespread infectious disease. If the prevalence of caries could be decreased, Americans could save the money, time, and personal pain involved with dental services for caries. A novel active ingredient has been explored as an additive for a dentifrice, extracted from the byproduct of wine-making, grape pomace. This polyphenolic extract shows strong inhibitory power toward the virulence factors of oral bacteria, such as the production of polysaccharides and acid. A consumer preference model is used to connect consumer survey data to a product composition for toothpaste, including the polyphenolic extract. This exercise results in a product composition that boasts 98% consumer satisfaction and a selling price that maximizes profit.
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COMMERCIALIZATION OF N2 RICH NATURAL GAS RESERVOIRS: With the natural gas supply in the United States not being able to support the nations demand for natural gas, the US will either have to find more sources for natural gas or import more natural gas from foreign countries. One of the potential sources to increase natural gas supply is to use nitrogen rich natural gas. The objective of this study is to identify and analyze potential uses for nitrogen rich natural gas reserves. An economic analysis will be shown on the feasibility of production and commercialization of nitrogen rich natural gas. The separation options include the purification of natural gas by cryogenic distillation, pressure swing adsorption, membranes, and molecular gate technology. The commercialization options include conversion of methane to synthesis gas and its derivates and combustion of natural gas for power generation. A mathematical model was built to determine the best process combination based on maximizing net present worth.
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TRANSPORTATION OF NATURAL GAS USING LIQUID CARRIERS AT AMBIENT TEMPERATURE
: Natural gas is currently transported with very established methods like Liquefied Natural Gas (LNG) and Compressed Natural Gas (CNG). A new technology is being researched for transporting natural gas at ambient temperatures and moderate pressures using liquefied hydrocarbons or other solvents. An economic analysis of this technology is essential to implementing it as a viable method for transportation. In this presentation we will cover the results of the economic impact of loading and unloading of the natural gas and the transportation itself. This method will also be compared to the existing methods. .
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USE OF MEMBRANES IN NATURAL GAS SEPARATIONS: Membranes are increasingly becoming a viable alternative to conventional gas separation technologies such as amine sweetening, pressure swing adsorption and cryogenic distillation. The design of an efficient and economically feasible membrane network is usually performed through step by step comparison of various designs, and flow patterns. We will present an optimization approach that allows the various designs to be compared simultaneously while choosing the optimal separation system. The model is based on mixed-integers nonlinear programming (MINLP) and is based on the concept of superstructures (all possible flowsheets put together from which one is picked).
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SWITCHGRASS TO FUELS: Due to government mandate requiring that an increasing percentage of gasoline be derived from renewable fuels, concerns about the environment, and a need to decrease U.S. dependence on foreign oil and fossil fuels, renewable resources have become an important research topic. In particular, there is a desire to develop a liquid fuel suitable for use in automotive engines. One process currently under consideration for this goal is pyrolysis of bio mass. This process uses switchgrass and other cellulosic material to produce a liquid bio-oil. This bio-oil contains too many oxygenates to be used in a car engine. Therefore, research into a catalytic deoxygenation process to upgrade this oil is underway. This presentation will evaluate the design of a pyrolysis and catalytic upgrading system that will produce a liquid fuel. The economic potential for this process will be highlighted and recommendations for future work will be provided.
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WATER MANAGEMENT IN PROCESS PLANTS: Water management in process plants have been the object of several studies in which the option of reusing water in effective ways has been explored. In addition, the possibility of regenerating freshwater out of polluted water to further reuse it has been mentioned. The extreme case of this is the so-called zero-liquid discharge cycles, which has been found possible and even economically beneficial in certain cases. One of the shortcomings of all these methods is that they do not incorporate good information about water treatment costs, both operating and investment. After explaining the overall problem and showing some of the exiting results, this presentation will focus on showing how one can generate generalized correlations of these costs so that they can be incorporated in the mathematical optimization models used to design water reuse/regeneration systems.
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GENERATION OF THERMOCHEMICAL CYCLES FOR H2 PRODUCTION THROUGH WATER SPLITTING: The diminishing supply of hydrocarbons and their negative environmental impact has resulted in a great need to find alternative energy sources. Hydrogen production from the chemical decomposition of water using multiple reactions resulting in the net production of hydrogen and oxygen are termed water splitting cycles. Previous work at OU focused on developing good efficiency evaluation procedures. In this presentation we describe a computer algorithm that was implemented to find new potential water splitting cycles and evaluate their thermodynamic feasibility. The goal is to find cycles that are viable at low reaction temperatures.
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ECONOMIC POTENTIAL OF STRANDED NATURAL GAS HYDRATES: With the supply of conventional energy sources on a decline and the demand for them increasing, the need for a large and stable supply of unconventional resources is growing fast. Natural gas hydrates are a potential source of large amounts of natural gas that can be found on the ocean floor and in permafrost regions, such as Alaska, Siberia and eastern Russia. This presentation shows the results of studies about the commercial feasibility of producing natural gas hydrates from the peninsula region of Kamchatka, Russia and selling it to markets in either China or Japan. A production model was constructed to determine the logistics of surface equipment placement. In addition, the difference in prices between transporting the produced natural gas via pipeline and tanker ship were compared. Preliminary calculations compare the commercial viability of constructing an LNG plant on the western coast of Kamchatka to selling gas to China via pipeline.
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EVALUATION OF LNG PRODUCTION
TECHNOLOGIES: There are numerous documented methods for the liquefaction of natural gas but only a handful are actually implemented commercially. The liquefaction process requires the natural gas to be cooled using various methods of cryogenic processes and also be depressurized to atmospheric conditions for easier and safer storage. This presentation shows the result of an analysis of twelve total processes based on their capacity, fixed costs and their operating efficiency. Eight of the eleven processes are currently established in various parts of the world. The four remaining processes are in developmental stages and each patent description is used to simulate each process and determine its feasibility in industry. The equipment and utility costs are determined for different capacities. The most economical processes as a function of capacity will be identified.
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